2. Gene
  3. PJA2 - praja ring finger ubiquitin ligase 2 Gene

PJA2 - praja ring finger ubiquitin ligase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：praja 无名指泛素连接酶 2

种属: Homo sapiens

同用名: RNF131; Neurodap1

基因 ID: 9867 | 基因类型: protein coding

关于 PJA2

Cytogenetic location: 5q21.3 Genomic coordinates (GRCh38): 5:109,334,722-109,409,974 (from NCBI)

This gene has 4 transcripts (splice variants), 155 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 108.1), thyroid (RPKM 63.6) and 24 other tissues.

功能概要

启用蛋白激酶 A 催化亚基结合活性；蛋白激酶 A 调节亚基结合活性；和泛素蛋白转移酶活性。参与多个过程，包括蛋白质泛素化；调节巨噬细胞活化；和信号转导的调节。位于细胞质中；中间丝细胞骨架；和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of macrophage activation; and regulation of signal transduction. Located in cytoplasm; intermediate filament cytoskeleton; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PJA2 基因产物(1)

mRNA Protein Name
NM_014819.5 NP_055634.3 E3 ubiquitin-protein ligase Praja-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28471450 GOA
enables protein kinase A catalytic subunit binding IMP
IMP: 通过突变表型推断
21423175 GOA
enables protein kinase A regulatory subunit binding IMP
IMP: 通过突变表型推断
21423175 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
33934390 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
21423175 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inflammatory response IMP
IMP: 通过突变表型推断
28471450 GOA
involved in innate immune response IMP
IMP: 通过突变表型推断
28471450 GOA
involved in positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
28471450 GOA
involved in positive regulation of p38MAPK cascade IMP
IMP: 通过突变表型推断
28471450 GOA
involved in positive regulation of toll-like receptor 2 signaling pathway IMP
IMP: 通过突变表型推断
28471450 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
33934390 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
21423175 GOA
involved in protein ubiquitination IMP
IMP: 通过突变表型推断
28471450 GOA
involved in regulation of macrophage activation IMP
IMP: 通过突变表型推断
28471450 GOA
involved in regulation of protein kinase A signaling IMP
IMP: 通过突变表型推断
21423175 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centriolar satellite IDA
IDA: 通过直接分析推断
33934390 GOA
located in centrosome IDA
IDA: 通过直接分析推断
33934390 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
21423175 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21423175 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PJA2 蛋白结构

zf-RING_2

zf-RING_2: Ring finger domain (634 - 675)

  • 0
  • 200
  • 400
  • 600
  • 708 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase Praja-2

RING-type E3 ubiquitin transferase Praja-2

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10589 PJA2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PJA2 VGNC VGNC:75817
Mus musculus PJA2 MGD MGI:2159342
Rattus norvegicus PJA2 RGD RGD:620273
Canis familiaris PJA2 VGNC VGNC:44595
Bos taurus PJA2 VGNC VGNC:32931
Felis catus PJA2 VGNC VGNC:64191
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