2. Gene
  3. LPGAT1 - lysophosphatidylglycerol acyltransferase 1 Gene

LPGAT1 - lysophosphatidylglycerol acyltransferase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶血磷脂酰甘油酰基转移酶 1

种属: Homo sapiens

同用名: NET8; FAM34A; LPLAT7; FAM34A1

基因 ID: 9926 | 基因类型: protein coding

关于 LPGAT1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,743,457-211,830,763 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in small intestine (RPKM 15.0), thyroid (RPKM 14.6) and 25 other tissues.

功能概要

该基因编码溶血磷脂酰基转移酶家族的一个成员。编码的蛋白质催化溶血磷脂酰甘油再酰化为磷脂酰甘油，磷脂酰甘油是一种膜磷脂，是心磷脂合成的重要前体。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 3 月]

This gene encodes a member of the lysophospholipid Acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

LPGAT1 基因产物(6)

mRNA Protein Name
NM_001320808.2 NP_001307737.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1
NM_001375841.1 NP_001362770.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1
NM_001375842.1 NP_001362771.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1
NM_001375844.1 NP_001362773.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2
NM_001375845.1 NP_001362774.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2
NM_014873.3 NP_055688.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 2-acylglycerophosphocholine O-acyltransferase activity IDA
IDA: 通过直接分析推断
36049524 GOA
enables lysophospholipid acyltransferase activity IDA
IDA: 通过直接分析推断
36049524 GOA
enables lysophospholipid acyltransferase activity IMP
IMP: 通过突变表型推断
15485873 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of fatty acid biosynthetic process IMP
IMP: 通过突变表型推断
23749231 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10942595 GOA
located in endoplasmic reticulum membrane IMP
IMP: 通过突变表型推断
15485873 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LPGAT1 蛋白结构

Acyltransferase

Acyltransferase: Acyltransferase (89 - 200)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
蛋白主名 其他名称

acyl-CoA:lysophosphatidylglycerol acyltransferase 1

acyl-CoA:monoacylglycerol acyltransferase LPGAT1

关联疾病

疾病名称 别名
Progressive Familial Heart Block, Type Ii

PFHB2

Pfhbii

Progressive Familial Heart Block Type Ii

Progressive Familial Heart Block Type 2

Heart Block Progressive Familial Type 2
Cardiomyopathy, Dilated, 1d

Dilated Cardiomyopathy 1d

CMD1D

Left Ventricular Noncompaction 6, Included

Lvnc6, Included

Left Ventricular Noncompaction 6

Cardiomyopathy, Dilated 1d
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07768 LPGAT1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21147 Lpgat1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27664 Lpgat1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LPGAT1 RGD RGD:1585897
Mus musculus LPGAT1 MGD MGI:2446186
Macaca mulatta LPGAT1 VGNC VGNC:74387
Bos taurus LPGAT1 VGNC VGNC:30965
Felis catus LPGAT1 VGNC VGNC:107894
Canis familiaris LPGAT1 VGNC VGNC:42750
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