2. Metabolic Enzyme/Protease Apoptosis
  3. Phospholipase Apoptosis
  4. GK563

GK563 是选择性的 Ca2+-independent phospholipase A2 (GVIA iPLA2) 抑制剂，IC50 值为 1 nM。GK563 对 GVIA iPLA2 的活性是 GIVA cPLA2 的 22000 倍。GK563 减少由促炎细胞因子诱导的 β-cell 凋亡，这提高了 GK563 对抗自身免疫性疾病 (如 1 型糖尿病) 的可能性。

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GK563 Chemical Structure

GK563 Chemical Structure

CAS No. : 2351820-19-2

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规格 价格 是否有货 数量
1 mg ￥1966
3 - 4 周
5 mg   询价  
10 mg   询价  

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GK563 相关抗体

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Phospholipase A PLD

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GK563 is a selective Ca2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes[1].

IC50 & Target

IC50: 1 nM (GVIA iPLA2), 22 μM (GVIA cPLA2)[1]
体外研究
(In Vitro)

GK563 (0.091 M) inhibits the activity of 100% GVIA iPLA2, 88% GVIA cPLA2 and 25% GV sPLA2[1].
GK563 (0-0.1 μM) inhibits GVIA iPLA2 with a XI(50) value of 0.0000021 and inhibits GVIA cPLA2 with an IC50 value of 22 μM[1].
GK563 (0-0.1 μM) shows a better inhibitory effect than fluoroketone FKGK18 to GVIA iPLA2 with an IC50 value of 1 nM[1].
GK563 (0-0.1 μM; 16 h) reduces β-cell apoptosis induced by proinflammatory cytokines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GK563 相关抗体:

Apoptosis Analysis[1]

Cell Line: β-cell line
Concentration: 0.1-10 μM
Incubation Time: 16 h
Result: Promoted a slight but modest rise in cell death when worked alone, but produced a concentration-dependent inhibition of β-cell apoptosis by the co-treatment of cells with cytokines.
分子量

246.34

Formula

C16H22O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GK563 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GK5632351820-19-2GK 563GK-563PhospholipaseApoptosisβ-lactone ringβ-cellapoptosisautoimmune diseaseproinflammatory cytokineInhibitorinhibitorinhibit

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目录号：
HY-138990
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