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  6. Goniothalenol

Goniothalenol 是一种从 Goniothalamus griffithii 中分离得到的苯乙烯内酯。Goniothalenol 对 A2780、HCT-8、KB 和 MCF-7 细胞系具有细胞毒活性。

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Goniothalenol Chemical Structure

Goniothalenol Chemical Structure

CAS No. : 65408-91-5

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Goniothalenol 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Goniothalenol is a styryl lactone that can be isolated from Goniothalamus griffithii. Goniothalenol exhibits cytatoxic activity against A2780, HCT-8, KB and MCF-7 cell lines[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
19 μM
Compound: 6
Antiproliferative activity against human CEM cells after 48 hrs by SRB assay
Antiproliferative activity against human CEM cells after 48 hrs by SRB assay
[PMID: 20036566]
L1210 IC50
2.9 μg/mL
Compound: 1
Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay
Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay
[PMID: 10479313]
MCF-12A IC50
120 μM
Compound: 6
Cytotoxicity against human MCF12A cells after 48 hrs by SRB assay
Cytotoxicity against human MCF12A cells after 48 hrs by SRB assay
[PMID: 20036566]
MCF7 IC50
124 μM
Compound: 6
Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 20036566]
RAW264.7 IC50
0.8 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 23735825]
RAW264.7 IC50
0.8 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IFN-beta mRNA expression by quantitative real-time PCR analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IFN-beta mRNA expression by quantitative real-time PCR analysis
[PMID: 23735825]
RAW264.7 IC50
0.9 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-6 mRNA expression by quantitative real-time PCR analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-6 mRNA expression by quantitative real-time PCR analysis
[PMID: 23735825]
RAW264.7 IC50
2 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced iNOS mRNA expression by quantitative real-time PCR analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced iNOS mRNA expression by quantitative real-time PCR analysis
[PMID: 23735825]
RAW264.7 IC50
3 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-1beta mRNA expression by quantitative real-time PCR analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IL-1beta mRNA expression by quantitative real-time PCR analysis
[PMID: 23735825]
RAW264.7 IC50
3 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced COX2 mRNA expression by quantitative real-time PCR analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced COX2 mRNA expression by quantitative real-time PCR analysis
[PMID: 23735825]
RAW264.7 IC50
4 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced G-CSF mRNA expression by quantitative real-time PCR analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced G-CSF mRNA expression by quantitative real-time PCR analysis
[PMID: 23735825]
RAW264.7 IC50
4 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced MCP1 mRNA expression by quantitative real-time PCR analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced MCP1 mRNA expression by quantitative real-time PCR analysis
[PMID: 23735825]
RAW264.7 IC50
43.4 μM
Compound: 2
Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTT assay
[PMID: 23735825]
RAW264.7 IC50
5 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IP-10 mRNA expression by quantitative real-time PCR analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induced IP-10 mRNA expression by quantitative real-time PCR analysis
[PMID: 23735825]
RAW264.7 IC50
6.7 μM
Compound: 2
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay
[PMID: 23735825]
分子量

232.23

Formula

C13H12O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Goniothalenol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Goniothalenol65408-91-5OthersStyryl lactoneGoniothalamus griffithiiCytatoxic activitiesA2780HCT-8KBMCF-7Inhibitorinhibitorinhibit

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