2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Neuronal Signaling GPCR/G Protein
  3. Glutathione Peroxidase Reactive Oxygen Species (ROS) Cannabinoid Receptor Ferroptosis
  4. GPX4-IN-18

GPX4-IN-18 (Compound 17) 是一种含二茂铁的谷胱甘肽过氧化物酶 4 (GPX4) 抑制剂。GPX4-IN-18 也是铁死亡的诱导剂。GPX4-IN-18 可以增加 OS-RC-2 透明细胞肾细胞癌细胞中 ROS 的产生和丙二醛 (MDA) 的水平。GPX4-IN-18 诱导 HT-1080 细胞发生铁死亡，IC50 分别为 0.007 μM (不存在铁抑制剂-1) 和 1.486 μM (存在铁抑制剂-1)。 GPX4-IN-18 降低了 OS-RC-2 异种移植小鼠模型中的体内肿瘤体积和肿瘤内 GPX4 水平。

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GPX4-IN-18

GPX4-IN-18 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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GPX4-IN-18 相关抗体

Top Publications Citing Use of Products

查看 Cannabinoid Receptor 亚型特异性产品:

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GPX4-IN-18 (Compound 17) is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4). GPX4-IN-18 is also an inducer of ferroptosis. GPX4-IN-18 can increase the production of ROS and malondialdehyde (MDA) levels in OS-RC-2 clear cell renal cell carcinoma cells. GPX4-IN-18 induces ferroptosis in HT-1080 cells with IC50s of 0.007 μM (absence of ferrostatin-1) and 1.486 μM (presence of ferrostatin-1). GPX4-IN-18 reduces in vivo tumor volume and intratumoral GPX4 levels in OS-RC-2 xenograft murine model[1].

分子量

554.84

Formula

C30H27ClFeN2O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GPX4-IN-18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPX4-IN-18Glutathione PeroxidaseReactive Oxygen Species (ROS)Cannabinoid ReceptorFerroptosisInhibitorinhibitorinhibit

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目录号：
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