1. Apoptosis
  2. RIP kinase
  3. GSK2983559

GSK2983559 (compound 3) 是一种具有口服活性且高效的受体相互作用蛋白 2 (RIP2) 激酶抑制剂。GSK2983559 在体内和人类炎症性肠病外植体样本中可阻断多种促炎细胞因子反应活性。

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GSK2983559 Chemical Structure

GSK2983559 Chemical Structure

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
5 mg ¥1331
In-stock
10 mg ¥1933
In-stock
25 mg ¥3383
In-stock
50 mg ¥4804
In-stock
100 mg ¥6822
In-stock
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500 mg   询价  

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Other Forms of GSK2983559:

查看 RIP kinase 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK2983559 is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1].

IC50 & Target[1]

RIPK2

 

体外研究
(In Vitro)

GSK2983559 (1-1024 nM;2 小时) 阻断 THP-1 细胞中 MDP 诱导的 IL-8[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: THP-1 cells
Concentration: 1-1024 nM
Incubation Time: 2 hours
Result: Inhibited IL-8 production with an IC50 of 1.34 nM.
体内研究
(In Vivo)

GSK2983559 (口服灌胃;3 和 10 mg/kg;一次) 在小鼠体内有效抑制 MDP 诱导的 IL-6[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (female) injected with MDP (100 μg)[2]
Dosage: 3 and 10 mg/kg
Administration: Oral gavage; 3 and 10 mg/kg; once
Result: Suppressed serum IL-6 levels in a dose-dependent manner.
Clinical Trial
分子量

612.63

Formula

C21H23N4O7PS2.1/2Ca.3H2O

性状

固体

颜色

Yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

DMF 中的溶解度 : < 1 mg/mL (insoluble)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

*GSK2983559 is usually formulated as a suspension.

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

GSK2983559 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
GSK2983559
目录号:
HY-112038A
需求量: