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  3. GW7604

GW7604 

目录号: HY-117153
产品使用指南

GW7604 是一种抗雌激素药。GW7604 是 GW5638 的代谢物。GW5638 是一种高亲和力的雌激素受体 (ER) 拮抗剂。

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GW7604 Chemical Structure

GW7604 Chemical Structure

CAS No. : 195611-82-6

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Description

GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist[1].

In Vitro

GW7604 is the presumed metabolite of GW5638 in breast (MCF-7) and endometrial (ECC-1) cell lines. GW7604 (0.1 nM-1 μM; 24 hours) inhibits both Estradiol (1 nM) and 4-hydroxytamoxifen (4-OHT; 10 and 100 nM) induction of TGF-alpha in a concentration related manner (1-1000 nM) in MDA-MB-231 cells[1].

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM
Incubation Time: 24 hours
Result: Blocked the effect of estradiol (E2; 1 n M) in a concentration-related manner.
Molecular Weight

370.44

Formula

C₂₅H₂₂O₃

CAS No.

195611-82-6

SMILES

O=C(O)/C=C/C1=CC=C(/C(C2=CC=C(O)C=C2)=C(C3=CC=CC=C3)/CC)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
GW7604
目录号:
HY-117153
需求量:

GW7604

Cat. No.: HY-117153