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  3. Haemanthamine hydrochloride

Haemanthamine hydrochloride 是从 Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱,具有强大的抗癌活性。Haemanthamine hydrochloride 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine hydrochloride 具有促凋亡,抗氧化剂,抗病毒,抗疟疾和抗惊厥活性。

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Haemanthamine hydrochloride Chemical Structure

Haemanthamine hydrochloride Chemical Structure

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规格 是否有货
5 mg
询价
10 mg
询价
25 mg
询价

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Other Forms of Haemanthamine hydrochloride:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

Haemanthamine (1-100 µM; 24-48 hours; A2780 cells) treatment shows a time- and dose-dependent decrease in cell viability[2].
Haemanthamine (10 µM; 24-72 hours; A2780 cells) treatment leads to a significant inhibition of A2780 cell proliferation[2].
Haemanthamine binds at the A-site cleft of the peptidyl transferase center on the large ribosomal subunit, creating unique molecular interactions with the 25S rRNA. Haemanthamine has a highly specific inhibitory effect on pre-rRNA processing, leading to the activation of a p53-dependent antitumoral surveillance pathway known as nucleolar stress[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours
Result: Showed a time- and dose-dependent decrease in cell viability.

Cell Proliferation Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Led to a significant inhibition of A2780 cell proliferation.
体内研究
(In Vivo)

A pharmacokinetic study of Haemanthamine in rats shows a rapid distribution phase of 30 min, a half-life of 70.4 min, and a major clearance through renal elimination. The high distribution volume of 13.7 L/kg suggests a high intracellular penetration, and its plasmatic concentration remains higher than 1 μM for at least 1 hr after a single 10-mg/kg administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

337.80

Formula

C17H20ClNO4

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Haemanthamine hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Haemanthamine hydrochloride
目录号:
HY-114489B
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