2. Anti-infection
  3. HBV
  4. HBV-IN-25

HBV-IN-25 是一种高效的新型 HBV cccDNA 还原剂，具有口服活性。HBV-IN-25 具有抗 HBeAg 和抗 HBV 活性，IC50 值分别为 0.58 μM 和 1.15 μM。HBV-IN-25 水溶性好 (LYSA>452 μg/mL)， PK 性能好，无细胞毒性。

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HBV-IN-25 Chemical Structure

HBV-IN-25 Chemical Structure

CAS No. : 2161364-69-6

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HBV-IN-25 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC50 values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA＞452 μg/mL) and good PK property with no cellular toxicity[1].

IC50 & Target

IC50: 0.58 μM (anti-HBeAg); 1.15 μM (anti-HBV)[1].
体外研究
(In Vitro)

HBV-IN-25 (8-50 μM, 5 days) has anti-HBeAg potency with an IC50 value of 0.58 μM.
HBV-IN-25 (8-50 μM, 5 days) has the anti-HBV activity in PHH is maintained or slightly decreased with IC50 value of 1.15 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HBV-IN-25 相关抗体:
体内研究
(In Vivo)

HBV-IN-25 (oral, 5, 20, 100, 300 mg/kg, single) has good PK property, and also shows excellent efficacy in significantly reducing HBV antigens, DNA, and intrahepatic cccDNA levels[1].
Pharmacokinetic Parameters of HBV-IN-25 inHBVcircle mouse model (oral, 5, 20, 100, 300 mg/kg, single)[1].

Dose Terminal body weight % versus day 1 Spinal cord inflammation Foci per 20 cells Spinal cord demyelination Score 0–5 Spinal cord apoptotic cells Count per section
PK parameter 5 mg/kg PO 20 mg/kg PO 100 mg/kg PO 300 mg/kg PO
Cmax(ng/kg) 828 8157 32200 59900
Tmax(ng/kg) 0.25 0.5 0.5 2.67
AUC0−∞(ng h/mL) 857 11,818 119,960 453,367
t1/2(h) 3.46 3.45 1.82
dose-normalized Cmax[(ng/mL)/(mg/kg)] 166 408 322 200
Dose-normalized AUC0−24h [(ng h/mL)/(mg/kg)] 171 591 1200 1511

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HBVcircle mouse model[1]
Dosage: 5, 20, 100, 300 mg/kg
Administration: oral, 5, 20, 100, 300 mg/kg, single
Result:
分子量

343.76

Formula

C18H14ClNO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HBV-IN-25 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBV-IN-252161364-69-6HBVHepatitis B virusHBV cccDNAanti-HBeAganti-HBVsolubilityPKtoxicityChronic hepatitis B virus (HBV)infectionInhibitorinhibitorinhibit

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