2. Metabolic Enzyme/Protease Apoptosis
  3. Carbonic Anhydrase Apoptosis
  4. hCAIX/XII-IN-1

hCAIX/XII-IN-1 是一种有效的 CAIX/XII 抑制剂，KI 值分别为 0.48 µM 和 0.83 µM。hCAIX/XII-IN-1 显示出体外抗增殖活性。hCAIX/XII-IN-1 诱导 MCF-7 细胞凋亡apoptosis。

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hCAIX/XII-IN-1 Chemical Structure

hCAIX/XII-IN-1 Chemical Structure

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hCAIX/XII-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the KI values of 0.48 µM and 0.83 µM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells[1].

IC50 & Target

KI: 0.48 µM (CAIX); 0.83 µM (CAXII)[1]
体外研究
(In Vitro)

hCAIX/XII-IN-1 (compound 11a) (3.125, 6.25, 12.5, 25, 50 µM, 48 h) shows antiproliferative activity with an IC50 value of 0.48 µM in MCF-7 cells[1].
hCAIX/XII-IN-1 (0.48 µM; 24 h) increases the cell populations of Sub-G1 phase[1].
hCAIX/XII-IN-1 (0.48 µM) induces apoptosis in MCF-7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hCAIX/XII-IN-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7 cells
Concentration: 3.125, 6.25, 12.5, 25, 50 µM
Incubation Time: 48 h
Result: Showed antiproliferative activity with an IC50 value of 0.48 µM in MCF-7 cells.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 0.48 µM
Incubation Time: 24 h
Result: Significantly increased the cell populations of Sub-G1 phase.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 0.48 µM
Incubation Time:
Result: Induced apoptosis in MCF-7 cells.
分子量

397.42

Formula

C19H11NO5S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCAIX/XII-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX/XII-IN-1Carbonic AnhydraseApoptosisCarbonate dehydrataseMCF-7 cellsapoptosisantiproliferativeSub-G1 phasecarbonic anhydraseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-146988
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