2. Metabolic Enzyme/Protease
  3. Cathepsin MMP
  4. Hepcidin-1 (mouse)

Hepcidin-1 (mouse) 是一种参与铁稳态调节的内源性肽激素。Hepcidin-1 (mouse) 上调 TRAP、组织蛋白酶 K 和 MMP-9 的 mRNA 水平并增加 TRAP-5b 蛋白分泌。Hepcidin-1 (mouse) 下调 FPN1 蛋白水平并增加细胞内铁。Hepcidin-1 (mouse) 促进破骨细胞分化。

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Custom Peptide Synthesis

Hepcidin-1 (mouse) Chemical Structure

Hepcidin-1 (mouse) Chemical Structure

CAS No. : 1676104-75-8

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Hepcidin-1 (mouse) 的其他形式现货产品:

Customer Review

Other Forms of Hepcidin-1 (mouse):

Hepcidin-1 (mouse) 相关抗体

Top Publications Citing Use of Products

查看 Cathepsin 亚型特异性产品:

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation[1].

IC50 & Target[1]

MMP-9

 

cathepsin K

 

体外研究
(In Vitro)

Hepcidin-1 mouse (200-800 nM，4 天) 促进 RANKL (50 ng/mL) 诱导的 raw264.7 细胞分化[1]。
Hepcidin-1 mouse (0-800 nM，4 天) 上调 TRAP、CTK 和 MMP-9 mRNA 的表达[1]。
Hepcidin-1 mouse (0-800 nM，20 小时) 会增加 RAW264.7 细胞中 Trap-5b 蛋白的水平并降低铁转运蛋白 1 (FPN1) 蛋白[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hepcidin-1 (mouse) 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 0, 200, 400, or 800 nM
Incubation Time: 20 h
Result: Decreased Ferroportin 1 (FPN1) protein.

Real Time qPCR[1]

Cell Line: RAW264.7 cells
Concentration: 0, 200, 400, or 800 nM
Incubation Time: 4 days
Result: Increased the gene expression of TRAP, CTK, and MMP-9 in a dose-dependent manner.
分子量

2754.24

Formula

C111H169N31O35S8
CAS 号
Sequence

Asp-Thr-Asn-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Lys-Cys-Cys-Asn-Asn-Ser-Gln-Cys-Gly-Ile-Cys-Cys-Lys-Thr (Disulfide bridge: Cys7-Cys23,Cys10-Cys22,Cys11-Cys19,Cys13-Cys14)
Sequence Shortening

DTNFPICIFCCKCCNNSQCGICCKT (Disulfide bridge: Cys7-Cys23,Cys10-Cys22,Cys11-Cys19,Cys13-Cys14)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hepcidin-1 (mouse) 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hepcidin-1 (mouse)1676104-75-8CathepsinMMPMatrix metalloproteinasesbiologically activepolypeptidepeptide screeningInhibitorinhibitorinhibit

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