HGS101 

HGS101 is a fully human CCR5 monoclonal antibody with high affinity to CCR5. HGS101 binds to the 2nd extracellular loop (ECL-2) and acts as a signal antagonist. HGS101 restores Maraviroc (HY-13004) inhibition of Maraviroc-resistant HIV-1 infection of PBMCs. HGS101 shows anti-HIV activity by inhibiting CCR5 signaling in simian immunodeficiency virus-uninfected RMs models^[1][2].

Human

CCR5/CD195

HGS101 (1 h) 在 JC6 细胞中存在 Maraviroc (HY-13004) 的条件下，对 Maraviroc 敏感型、耐药型和 Maraviroc 耐药的 HIV-1 的 EC₅₀ 值分别为 0.001 μg/mL、0.0003 μg/mL 和0.00002 μg/mL^[1]。

HGS101 (1 h) 在 PBMCs 中存在 Maraviroc 的条件下，对 Maraviroc 敏感型、耐药型和 Maraviroc 耐药的 HIV-1 的 EC₅₀ 值分别为 0.03 μg/mL、0.0 3 μg/mL 和 0.01 μg/mL^[1]。

HGS101 (0.3 µg/ mL, 1 h) 可以恢复 PBMCs 中 Maraviroc 对 Maraviroc 耐药的 HIV-1 的抑制作用，使 Maraviroc 的 EC₅₀ 值降低为 0.007 nM^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HGS101(10 mg/kg，静脉注射，每 15 天 1 次，持续 10 次) 在未感染猴免疫缺陷病毒的恒河猴模型中通过抑制 CCR5 信号通路发挥抗 HIV 的作用^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1234  [NCBI]

P51681

CCR5/CD195

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Latinovic O, et al. CCR5 antibodies HGS004 and HGS101 preferentially inhibit drug-bound CCR5 infection and restore drug sensitivity of Maraviroc-resistant HIV-1 in primary cells. Virology. 2011 Mar 1;411(1):32-40.  [Content Brief]

  [2]. aaffe JE, et al. CCR5 blockade is well tolerated and induces changes in the tissue distribution of CCR5+ and CD25+ T cells in healthy, SIV-uninfected rhesus macaques. J Med Primatol. 2012 Feb;41(1):24-42.  [Content Brief]