2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Cytochrome P450
  4. HIV-1 inhibitor-40

HIV-1 inhibitor-40 (Compound 4ab) 是一种 HIV-1 非核苷型逆转录酶抑制剂(NNRTI)，EC50 为 1.9 nM。HIV-1 inhibitor-40 对 CYP 的敏感性较低，对 CYP2C9 和 CYP2C19 的 IC50 值分别为 5.16 μM 和 4.51 μM。HIV-1 inhibitor-40 在体内无明显急性毒性。

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HIV-1 inhibitor-40 Chemical Structure

HIV-1 inhibitor-40 Chemical Structure

CAS No. : 2789676-44-2

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HIV-1 inhibitor-40 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HIV-1 inhibitor-40 (Compound 4ab) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an EC50 of 1.9 nM. HIV-1 inhibitor-40 displays weak CYP sensitivity with IC50 values of 5.16 μM and 4.51 μM against CYP2C9 and CYP2C19, respectively. HIV-1 inhibitor-40 has no apparent in vivo acute toxicity[1].

IC50 & Target

HIV-1 (WT)

1.9 nM (EC50)

HIV-1 (K103N)

0.004 μM (EC50)

HIV-1 (E138K)

0.009 μM (EC50)

HIV-1 (L100I)

0.019 μM (EC50)

HIV-1 (Y181C)

0.029 μM (EC50)

HIV-1 (Y188L)

0.570 μM (EC50)

CYP2C19

4.51 μM (IC50)

CYP2C9

5.16 μM (IC50)

体外研究
(In Vitro)

HIV-1 inhibitor-40 (Compound 4ab) displays inhibitory activity with EC50 values of 0.019 ± 0.005, 0.004 ± 0.001, 0.029 ± 0.007, 0.570 ± 0.099 and 0.009 ± 0.006 μM against L100I, K103N, Y181C, Y188L and E138K HIV-1 mutant strains, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HIV-1 inhibitor-40 相关抗体:
分子量

434.45

Formula

C25H18N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HIV-1 inhibitor-40 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-402789676-44-2HIVCytochrome P450Human immunodeficiency virusCYPsMT-4no apparent acute toxicityInhibitorinhibitorinhibit

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目录号：
HY-147807
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