1. Anti-infection Cell Cycle/DNA Damage
  2. HIV DNA/RNA Synthesis
  3. HIV-1 inhibitor-43

HIV-1 inhibitor-43 是一种有效的 HIV-1 抑制剂,对 HIV-1 Y188L、K103N-Y181C、K103N 和 Y181C 的 EC50 分别为 21.3 nM、6.2 nM、< 0.7 nM 和 < 0.7 nM。HIV-1 inhibitor-43 可降低 HIV-1 RNA 和蛋白 p24 表达。

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HIV-1 inhibitor-43 Chemical Structure

HIV-1 inhibitor-43 Chemical Structure

CAS No. : 2493426-43-8

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生物活性

HIV-1 inhibitor-43 is a potent HIV-1 inhibitor with an EC50 of 21.3 nM, 6.2 nM, < 0.7 nM and < 0.7 nM for Y188L, K103N-Y181C, K103N and Y181C, respectively. HIV-1 inhibitor-43 can reduce HIV-1 RNA and protein p24 expression[1].

IC50 & Target[1]

HIV-1 (Y188L)

21.3 nM (EC50)

HIV-1 (K103N+Y181C)

6.2 nM (EC50)

HIV-1 (K103N)

<0.7 nM (EC50)

HIV-1 (Y181C)

<0.7 nM (EC50)

体外研究
(In Vitro)

HIV-1 inhibitor-43 (compound 12) has anti-HIV-1 activity against HIV-1 reverse transcriptase with IC50s of 83±8 nM, 73±8 nM, 61±6 nM and 76±8 nM for HIV-1 WT, K103N, Y181I and K103N-Y181I, respectively[1].
HIV-1 inhibitor-43 (1, 5 and 25 nM) causes 100% reduction of HIV-1 RNA and protein p24 at 25 nM in C8166 cells infected with a WT strain[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

468.95

Formula

C24H21ClN2O4S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
HIV-1 inhibitor-43
目录号:
HY-150599
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