2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. HSP70-IN-7

HSP70-IN-7 是一种非选择性 HSP70 抑制剂，对 HSP70、GRP75 和 GRP78 的 Kd 分别为 4.71、2.16 和 2.93 μM。HSP70-IN-7 对乳腺癌细胞具有选择性毒性，可诱导细胞凋亡 (apoptosis)，并有效抑制乳腺癌干细胞 (BCSC) 的特性。HSP70-IN-7 可用于乳腺癌研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

HSP70-IN-7

HSP70-IN-7 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

HSP70-IN-7 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HSP70-IN-7 is a nonselective HSP70 inhibitor with Kds of 4.71, 2.16 and 2.93μM against HSP70, GRP75, and GRP78. HSP70-IN-7 exhibits selective toxicity against breast cancer cells, induces cell apoptosis and effectively suppresses the properties of breast cancer stem cells (BCSCs). HSP70-IN-7 can be used for the study of breast cancer[1].

IC50 & Target[1]

HSP70

4.71 μM (Ki)

体外研究
(In Vitro)

HSP70-IN-7 (compound 5) (48 h) 抑制乳腺癌细胞增殖，对 MDA-MB-231、BT549、MCF7 和 CAMA1 细胞的 IC50 值分别为 0.793、0.297、0.863 和 0.6 μM[1]。
HSP70-IN-7 (1 μM, 48 h) 诱导 NS/GRP75 shRNA 转染的 BT549 细胞稳定克隆发生细胞凋亡[1]。
HSP70-IN-7 (0.5-1 μM, 10-14 d) 抑制 MDA-MB-231 细胞的集落形成和乳球形成[1]。
HSP70-IN-7 (1 μM, 0-1 h) 直接作用于线粒体 GRP75，破坏其 PPI，从而导致 BT549 细胞中的线粒体膜通透化和 Cyt c 释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HSP70-IN-7 相关抗体:

Apoptosis Analysis[1]

Cell Line: BT549 cells
Concentration: 1 μM
Incubation Time: 48 h
Result: Induced cell apoptosis.
分子量

958.08

Formula

C55H66BrN4O2PS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HSP70-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP70-IN-7HSPApoptosisHeat shock proteinsSubcellular AnchoringIsoform-Selective Inhibition?Breast Cancer Stem CellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HSP70-IN-7
目录号：
HY-175865
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z