2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. HSP90-IN-18

HSP90-IN-18 是一种有效的热休克蛋白 90 (Hsp90) 抑制剂。HSP90-IN-18 具有有效的 Hsp90 抑制活性，IC50 值为 0.39 μM。HSP90-IN-18 可用于病毒感染、神经退行性疾病和炎症的研究。

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HSP90-IN-18 Chemical Structure

HSP90-IN-18 Chemical Structure

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HSP90-IN-18 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HSP90-IN-18 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC50 value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation[1].

IC50 & Target

IC50: 0.39 μM (Hsp90); 17.65 μM (MCF-7); 20.03 μM (SW480); ＞40 μM (A549); 3.69 μM (HL60); 11.92 μM (SMMC-7721)[1]
体外研究
(In Vitro)

HSP90-IN-18 具有有效的 Hsp90 抑制活性，IC50 值为 0.39 μM[1]。
HSP90-IN-18 (40, 8, 1.6, 0.32, 0.064 μM; 48 h) 对 MCF-7、SW480、A549、HL60 和 SMMC-7721 具有抗增殖活性，IC50 值分别为 17.65 μM、20.03 μM、＞40 μM、3.69 μM 和 11.92 μM[1]。
HSP90-IN-18 (0, 1, 5, 10, 20 μM; 12-16 h) 通过线粒体介导的细胞凋亡途径促进 HL-60 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HSP90-IN-18 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HL-60, A549, SMMC7721, MCF-7 and SW480 cell lines
Concentration: 40, 8, 1.6, 0.32, 0.064 μM
Incubation Time: 48 h
Result: Showed much better anti-proliferation activities in five cancer cell lines, especially against human leukocyte cell line.

Apoptosis Analysis[1]

Cell Line: HL-60 cells
Concentration: 0, 1, 5, 10, 20 μM
Incubation Time: 12-16 h
Result: Promoted the apoptosis of HL-60 cells.

Western Blot Analysis[1]

Cell Line: HL-60 cells
Concentration: 0, 1, 5, 10 μM
Incubation Time: 24 h
Result: Showed the expression of Bcl2 was significantly reduced, while Bax was increased.
体内研究
(In Vivo)

HSP90-IN-18（i.p.；100 mg/kg；持续 14 天）抑制 H22 荷瘤小鼠模型中的肿瘤生长，并显示出对小鼠的低急性毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming Mice (female; 18–20g)[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal administration for 14 days
Result: Showed normal behavior and feeding habits without any signs of toxicity and demonstrated low acute toxicity (LD50 > 500 mg/kg).
分子量

400.53

Formula

C25H33FO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HSP90-IN-18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP90-IN-18HSPApoptosisHeat shock proteinsheat shock protein 90 (Hsp90)viral infectionneurodegenerative diseaseinflammationInhibitorinhibitorinhibit

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产品名称：
HSP90-IN-18
目录号：
HY-152027
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