2. Inhibitory Antibodies
  3. Ianalumab

Ianalumab  (Synonyms: VAY-736)

目录号: HY-P99653 纯度: 95.00%
COA

摩尔计算器

Ianalumab (VAY-736) 是一种针对 BAFF-R 的人源、脱羧化抗体。Ianalumab 能够阻断 BAFF 与 BAFF-R 之间的相互作用，拮抗 BAFF 介导的凋亡保护。Ianalumab 具有抗体依赖性细胞毒性 (ADCC)，依赖于免疫受体酪氨酸激活基序 (ITAM) 介导的效应细胞激活。

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Ianalumab Chemical Structure

Ianalumab Chemical Structure

CAS No. : 1929549-92-7

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Ianalumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ianalumab (VAY-736) is a human, decarboxylated antibody against BAFF-R. Ianalumab can block the interaction between BAFF and BAFF-R and antagonize the apoptosis protection mediated by BAFF. Ianalumab exerts antibody-dependent cytotoxic (ADCC), depending on effector cell activation mediated by immune receptor tyrosine activation motif (ITAM)[1].

IC50 & Target

BAFF-R[1]
体外研究
(In Vitro)

Ianalumab (0.1 μg/mL; 72 h) 对慢性淋巴细胞白血病 (CLL) 自然杀伤细胞的强抗体依赖性细胞毒性 (ADCC)，促进细胞因子的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ianalumab 相关抗体:
体内研究
(In Vivo)

Ianalumab (总剂量: 100 mg/kg; 每周一次, 持续 2 周) 增加 CLL 小鼠模型的小鼠存活率[1]。
Ianalumab (10 mg/kg; 每周一次, 持续 6 周) 经 Ibrutinib (HY-10997) 调节 NK 细胞的 ITAM 后，表现出功能增强[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Em-TCL1 adoptive transplant model of murine CLL[1]
Dosage: 10 mg/kg
Administration: Injection; once weekly for 6 weeks
Result: Ibrutinib enhanced VAY-736 activity through an ITAM function on NK cells.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

  • 摩尔计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ianalumab1929549-92-7VAY-736VAY736VAY 736OthersInhibitorinhibitorinhibit

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