2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Iberiotoxin

Iberiotoxin 是一种从 Buthus tamulus 毒液中分离出来的毒素。Iberiotoxin 是一种选择性的高电导率 Ca2+ 激活的 K+ 通道 (Ca2+-activated K+ channel) 抑制剂，Kd 约为 1 nM。Iberiotoxin 不阻断其他类型的电压依赖性离子通道。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Iberiotoxin TFA 通常具有更好的水溶性和稳定性。

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Custom Peptide Synthesis

Iberiotoxin Chemical Structure

Iberiotoxin Chemical Structure

CAS No. : 129203-60-7

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规格 价格 是否有货
100 μg ￥3800
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Iberiotoxin 的其他形式现货产品:

Customer Review

Other Forms of Iberiotoxin:

Iberiotoxin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca2+-activated K+ channel inhibitor with a Kd of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels[1][2][3].

IC50 & Target

Kd: 1 nM (Ca2+-activated K+ channel)[1][3]
体外研究
(In Vitro)

Iberiotoxin reversibly blocks Ca2+-activated K+ channel in excised membrane patches from bovine aortic smooth muscle. Iberiotoxin acts exclusively at the outer face of the channel and functions with IC50 values of about 250 pM. Iberiotoxin is a partial inhibitor of 125I-charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (Ki of 250 pM). Iberiotoxin functions as a noncompetitive inhibitor of charybdotoxin binding[1].
Iberiotoxin treatment affects rat mesenchymal stem cells (rMSCs) migration in the absence of platelet lysate (PL) by inducing a decrease in cell migration suggesting that BK channels regulate rMSCs migration in basal conditions. 10 nM of Iberiotoxin abolishes the PL-induced migration effect on MSCs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Iberiotoxin 相关抗体:
体内研究
(In Vivo)

Male Wistar rats (6-7 weeks old) with chronic heart failure (CHF), Iberiotoxin (0.125 nmol/nl, 1.25 nmol/nl and 12.5 nmol/nl) is infused into paraventricular hypothalamic nucleus (PVN) by osmotic minipumps. After perfusion of Iberiotoxin by microinjection of rAAV2-KCNMB4 shRNA virus, right ventricular weight/body weight and lung weight/body weight ratio as well as left ventricular end-diastolic diameter are increased and left ventricular ejection fraction is decreased[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4230.85

Formula

C179H274N50O55S7
CAS 号
性状

固体

颜色

White to off-white

Sequence

{Glp}-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln (Disulfide bridge:Cys7-Cys28,Cys13-Cys33,Cys17-Cys35)
Sequence Shortening

{Glp}-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ (Disulfide bridge:Cys7-Cys28,Cys13-Cys33,Cys17-Cys35)
结构分类
初始来源

Buthus tamulus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 0.7 mg/mL (0.17 mM)

* "≥" means soluble, but saturation unknown.

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (171 KB)

产品使用指南 (1538 KB)
参考文献

Iberiotoxin 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iberiotoxin129203-60-7Potassium ChannelKcsABKmigrationplateletlysatepeptidylKCacharybdotoxin,Inhibitorinhibitorinhibit

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产品名称：
Iberiotoxin
目录号：
HY-P0190
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