1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)
  3. IDO1-IN-2

IDO1-IN-2 (compound 16) 是一种有效的选择性 IDO1 抑制剂,IC50 分别为 81 nM,59 nM (小鼠)和 28 nM (大鼠)。IDO1-IN-2 具有抗癌活性。

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IDO1-IN-2 Chemical Structure

IDO1-IN-2 Chemical Structure

CAS No. : 2346614-58-0

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查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity[1].

IC50 & Target[1]

IDO1

81 nM (IC50)

体外研究
(In Vitro)

IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC50 of 49 nM. IDO1-IN-2 has an IC50 of 249 nM for IDO1 wholr blood[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

IDO1-IN-2 (100 mg/kg, twice daily) demonstrates good efficacy synergy when combined with anti-PD-1 mAb in a mouse EMT6 tumor syngeneic model[1].
IDO1-IN-2 has a t1/2 of 3.7 hours, a CL/CLu of 15/319 mL/min/kg, and a F of 63% for rats. IDO1-IN-2 has a t1/2 of 6 hours, a CL/CLu of 6/88 mL/min/kg, and a F of 67% for dogs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

364.33

Formula

C15H17FN6O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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IDO1-IN-2
目录号:
HY-130607
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