2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Indoleamine 2,3-Dioxygenase (IDO) Reactive Oxygen Species (ROS)
  4. IDOi-Pt(IV) prodrug-1

IDOi-Pt(IV) prodrug-1 (Compound 10) 是一种 IDOi-Pt(IV) 前药。IDOi-Pt(IV) prodrug-1 抑制 IDO 表达。IDOi-Pt(IV) prodrug-1 诱导细胞凋亡 (apoptosis)，降低线粒体膜电位，抑制肿瘤细胞迁移和侵袭。IDOi-Pt(IV) prodrug-1 诱导活性氧介导的内质网应激和损伤相关分子模式 (DAMPs) 的分泌，从而呈现免疫原性细胞死亡 (ICD) 效应。与顺铂 (HY-17394) 相比，IDOi-Pt(IV) prodrug-1 具有相对高效、低毒的抗肿瘤作用。

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IDOi-Pt(IV) prodrug-1

IDOi-Pt(IV) prodrug-1 Chemical Structure

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IDOi-Pt(IV) prodrug-1 相关抗体

Top Publications Citing Use of Products

查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

查看所有亚型
IDO1 IDO2 IDO

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDOi-Pt(IV) prodrug-1 (Compound 10) is an IDOi-Pt(IV) prodrug. IDOi-Pt(IV) prodrug-1 inhibits IDO expression. IDOi-Pt(IV) prodrug-1 induces apoptosis, decreases the mitochondrial membrane potential, inhibits tumor cell migration and invasion. IDOi-Pt(IV) prodrug-1 induces reactive oxygen species-mediated endoplasmic reticulum stress and secretion of damage-associated molecular patterns (DAMPs), thereby presenting immunogenic cell death (ICD) effects. IDOi-Pt(IV) prodrug-1 has high-efficiency and low-toxicity antitumor effects compared to Cisplatin (HY-17394)[1].

分子量

749.96

Formula

C21H26Cl3N3O6PtS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDOi-Pt(IV) prodrug-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDOi-Pt(IV) prodrug-1ApoptosisIndoleamine 2,3-Dioxygenase (IDO)Reactive Oxygen Species (ROS)Inhibitorinhibitorinhibit

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目录号：
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