2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Idoxuridine hydrate

Idoxuridine hydrate  (Synonyms: 5-Iodo-2′-deoxyuridine hydrate; 5-IUdR hydrate; IdUrd hydrate)

目录号: HY-B0307A
产品使用指南

摩尔计算器

Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate 是一种碘化的胸苷类似物，可竞争性抑制磷酸化酶 (phosphorylases)。 Idoxuridine 可以通过抑制 DNA 聚合酶 (DNA polymerase)，影响病毒的复制，从而抑制病毒活性，特别是眼部病毒性感染，包括单纯疱疹性角膜炎。Idoxuridine 作用于猫疱疹病毒的 IC50 值为 4.3 μM。

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Idoxuridine hydrate Chemical Structure

Idoxuridine hydrate Chemical Structure

CAS No. : 17140-71-5

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Idoxuridine hydrate 的其他形式现货产品:

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Other Forms of Idoxuridine hydrate:

Idoxuridine hydrate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM[1].

体外研究
(In Vitro)

Idoxuridine (2-10 μM, 72 hours) hydrate has the IC50 value of 4.3 μM of antiviral[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Idoxuridine hydrate 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Crandell-Reese feline kidney (CRFK) cells
Concentration: 2-10 μM
Incubation Time: 72 hours
Result: Showed the IC50 value of 4.3 μM.

Cell Cytotoxicity Assay[1]

Cell Line: Crandell-Reese feline kidney (CRFK) cells
Concentration: 5-50 μM
Incubation Time: 72 hours
Result: Reduced by 10.8% relatively in CRFK cells.
体内研究
(In Vivo)

Idoxuridine (intraperitoneal injection, 50-200 mg/kg, 3 times, 3 hours interval) hydrate can stimulate the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in C3HeB/FeJ female and male mice and A/J male mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3HeB/FeJ female and male mice and A/J male mice, aged 2 to 4 months[2]
Dosage: 50-200 mg/kg
Administration: Intraperitoneal injection, 3 times, 3 hours interval
Result: Stimulated the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in the dose range of 50-200 mg/kg.
Clinical Trial
分子量

372.11

Formula

C9H13IN2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Idoxuridine hydrate 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Idoxuridine17140-71-55-Iodo-2′-deoxyuridine5-IUdRIdUrdPhosphataseAntiviral agentsPhosphorylases inhibitorDNA polymeraseHerpesvirusesFeline herpesvirusIodinated thymidine analogueInhibitorinhibitorinhibit

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