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  3. Ilimaquinone

Ilimaquinone 是一种海洋海绵状代谢产物,通过 GADD153 介导的信号通路发挥抗肿瘤活性。Ilimaquinone 可以诱导高尔基体的囊泡化。Ilimaquinone 具有抗病毒,抗菌和抗炎活性。

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Ilimaquinone Chemical Structure

Ilimaquinone Chemical Structure

CAS No. : 71678-03-0

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100 μg ¥3200
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus[1]. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects[2].

体外研究
(In Vitro)

Ilimaquinone induces a concentration-dependent anti-proliferative effect in several types of cancer cell lines, including prostate cancer PC-3 and LNCaP, non-small cell lung cancer A549 and hepatocellular carcinoma Hep3B cells. Ilimaquinone (0.3-30 μM ; 48 hours) inhibits the proliferation of PC-3 cells, DU145, LNCaP, MG63, A549, Hep3B cells with GI50s of 2.6 μM, 5.8, 4.6, 4.9, 4.1, 12.0μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Prostate cancer PC-3 cells
Concentration: 0.3, 1, 3, 10, and 30 μM
Incubation Time: 48 hours
Result: Inhibited the proliferation of PC-3 cells in a concentration-dependent manner.
体内研究
(In Vivo)

Ilimaquinone exhibits terminal elimination half-lives (T1/2=1.2±0.3 h) due to high plasma clearance (2.95±0.53 L/h/kg) following oral administration (10 mg/kg) in male Sprague-Dawley rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

358.47

Formula

C22H30O4

CAS 号
性状

固体

颜色

Light yellow to brown

结构分类
初始来源

marine sponge Halichondria sp.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

参考文献

Ilimaquinone 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Ilimaquinone
目录号:
HY-119500
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