2. Apoptosis Immunology/Inflammation Membrane Transporter/Ion Channel
  3. TNF Receptor Interleukin Related Potassium Channel
  4. Immuno modulator-1

Immuno modulator-1 (compound 22) 抑制人外周血单核细胞 (hPBMC) 中 TNFα 和 IL-2 的分泌，IC50 值分别为 4.7 和 26 nM 。Immuno modulator-1 具有 hERG 钾通道阻断作用，3 μM时抑制率为20%。

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Immuno modulator-1 Chemical Structure

Immuno modulator-1 Chemical Structure

CAS No. : 2757469-20-6

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Immuno modulator-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM[1].

IC50 & Target

IL-2

 

体外研究
(In Vitro)

Immuno modulator-1 (compound 22) 抑制 NCI-H929 人骨髓瘤细胞的增殖，IC50 为 0.6 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Immuno modulator-1 相关抗体:
体内研究
(In Vivo)

Immuno modulator-1 (compound 22) (1 mg/kg (IV), 5 mg/kg (PO); once) 在雄性 Sprague-Dawley 大鼠中的口服生物利用度为30%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 1 mg/kg (IV), 5 mg/kg (PO)
Administration: IV (2 mL/kg), PO (10 mL/kg); once (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of Immuno modulator-1 in male Sprague-Dawley rats[1].
IV (1 mg/kg) PO (5 mg/kg)
Cmax (ng/mL) 1437
AUC0-24 (ng/mL∗h) 13029
CL (mL/min/kg) 2.2
Vss (L/kg) 0.36
F (%) 30%
分子量

582.62

Formula

C32H31FN6O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Immuno modulator-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Immuno modulator-12757469-20-6Immuno modulator1Immuno modulator 1TNF ReceptorInterleukin RelatedPotassium ChannelTumor Necrosis Factor ReceptorTNFRILKcsAhPBMCNCI-H929myeloma cellperipheral blood mononuclear cellsInhibitorinhibitorinhibit

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