Inuviscolide 

Inuviscolide is an apoptosis inducer. Inuviscolide can induce of G₂/M arrest in human melanoma cell lines. Inuviscolide exhibits antineoplastic and anti-inflammatory activities^[1][2][3].

Inuviscolide (9-72 μM; 24 h) 抑制 SK-28，624 和 1363 黑色素瘤细胞的增殖，IC₅₀ 值分别为 37，41.1 和 39 μM^[2]。
Inuviscolide (36-54 μM; 4-24 h) 导致 SK-28 细胞在 G₂/M 期发生剂量依赖性积累^[2]。
Inuviscolide (72 μM; 48 h) 导致约 70% 的 SK-28 细胞表现出早期凋亡标志物^[2]。
Inuviscolide 在 100 μM 时抑制人白细胞弹性蛋白酶的释放 51%^[1]。
Inuviscolide 抑制蜂毒分泌的 PLA₂ (sPLA₂)，IC₅₀ 值为 80.5 μM^[1]。
Inuviscolide 在 50 μM 时抑制 COX-1 (40%)，而它对诱导型 COX-2 没有活性^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Inuviscolide 减少了反复应用 12-O-tetradecanoylphorbol 13-acetate 诱导的皮炎小鼠皮肤白细胞浸润^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

248.32

C₁₅H₂₀O₃

63109-30-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Máñez S, et, al. Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa. Fitoterapia. 2007 Jun;78(4):329-31.  [Content Brief]

  [2]. Rozenblat S, et, al. Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines. Biochem Pharmacol. 2008 Jan 15;75(2):369-82.  [Content Brief]

  [3]. Hernández V, et, al. A mechanistic approach to the in vivo anti-inflammatory activity of sesquiterpenoid compounds isolated from Inula viscosa. Planta Med. 2001 Nov;67(8):726-31.  [Content Brief]