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Iscalimab  (Synonyms: CFZ-533; OM11-62MF)

目录号: HY-P99670 纯度: 99.15%
COA

Iscalimab (CFZ-533) 是一种非耗竭性 IGg1 单克隆抗体,靶向 CD40 (KD: 0.3 nM)。Iscalimab 可用于 Graves 甲状腺功能亢进症和自身免疫性疾病的研究。

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Iscalimab Chemical Structure

Iscalimab Chemical Structure

CAS No. : 2031153-61-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting CD40 (KD: 0.3 nM). Iscalimab can be used for research of Graves' hyperthyroidism and autoimmune diseases[1][2][3].

IC50 & Target[1]

CD40

0.3 nM (IC50)

体外研究
(In Vitro)

Iscalimab (0.01-1 μg/mL,过夜) 抑制 rCD154 诱导的原代单核细胞衍生树突状细胞 (moDC) 产生 TNF,IC50 为 0.04 μg/mL[3]
Iscalimab (3 天) 抑制 rCD154 诱导的人、恒河猴和食蟹猴 PBMC 增殖,IC50 分别为 0.02、0.03 和 0.01 μg/mL[3]
Iscalimab 结合来自人、恒河猴和食蟹猴的 B 细胞上的 CD40,EC50 值约为 0.2 μg/mL[3]
Iscalimab (2 μg/mL, 3 h) 以 CD40 依赖性方式被 B 细胞内化[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: PBMCs from humans, rhesus and cynomolgus animals
Concentration: 0-1 μg/mL approximately
Incubation Time: 3 days
Result: Inhibited rCD154-induced proliferation of PBMCs with IC50s of 0.02, 0.03, and 0.01 μg/mL, respectively.
体内研究
(In Vivo)

Iscalimab (150 mg/kg/周,皮下注射,持续 13 周) 耐受性良好,不会对恒河猴造成任何剂量限制性毒性[3]
Iscalimab (10 mg/kg,静脉注射) 完全抑制恒河猴的 T 细胞依赖性抗体反应[3]
Iscalimab (30 mg/kg,静脉内) 可延长肾移植食蟹猴的同种异体移植物存活期[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kidney transplant cynomolgus[4]
Dosage: 30 mg/kg
Administration: i.v.
Result: Prolonged allograft survival.
Well-tolerated with no evidence of thromboembolic events or CD40 pathway activation.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Iscalimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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