2. Apoptosis
  3. Apoptosis
  4. JBC117

JBC117 是一种靶向 Pygo2 PHD 指的新型抗癌先导化合物。JBC117 能有效拮抗 β-catenin 依赖活性的细胞效应，并抑制癌细胞的迁移和侵袭。JBC117 可诱导肿瘤细胞凋亡(apoptosis)。

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JBC117 Chemical Structure

JBC117 Chemical Structure

CAS No. : 1214531-21-1

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JBC117 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JBC117 is a novel anticancer lead compound targeting Pygo2 PHD. JBC117 can effectively antagonize the cell effect of β-catenin-dependent activity and inhibit the migration and invasion of cancer cells. JBC117 can induce apoptosis[1].

体外研究
(In Vitro)

JBC117 (20 μM, 24 h) 可抑制结肠癌 (HCT116) 和肺癌 (A549) 的生长，IC50 值分别为 2.6 和 3.3 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JBC117 相关抗体:

Western Blot Analysis[1]

Cell Line: HCT116, A549
Concentration: 5, 10, 20 μM
Incubation Time: 72 h
Result: Downregulated the expression level of Wnt downstream target genes, including Axin2, c-myc and cyclin D1.

Cell Invasion Assay[1]

Cell Line: HCT116, A549
Concentration: 20 μM
Incubation Time: 24 h
Result: Decreased the ability to migrate and invasion in a dose-dependent manner.
体内研究
(In Vivo)

JBC117 (20 mg/kg/天, 皮下注射, 连续 14 天) 在小鼠结肠癌和肺癌异种移植模型中具有抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse xenograft models of colon and lung cancer[1]
Dosage: 20 mg/kg
Administration: s.c. for 14 days
Result: Reduced colon and lung tumor growth by 65% and 93%, respectively.
Increased apoptosis in the tumor sections.
分子量

442.55

Formula

C28H30N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JBC117 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JBC1171214531-21-1JBC 117JBC-117ApoptosisPygo2 PHDHCT116A549AntitumorInhibitorinhibitorinhibit

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