2. MAPK/ERK Pathway
  3. JNK
  4. JNK3 inhibitor-7

JNK3 inhibitor-7 是一种有效的、具有口服活性并可穿过血脑屏障的 JNK3 抑制剂，对 JNK3、JNK2、JNK1 的 IC50 值分别为 53、973、1039 nM。JNK3 inhibitor-7 显示出显着的神经保护作用。JNK3 inhibitor-7 具有研究阿尔茨海默病 (AD) 的潜力。

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JNK3 inhibitor-7 Chemical Structure

JNK3 inhibitor-7 Chemical Structure

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JNK3 inhibitor-7 相关抗体

Top Publications Citing Use of Products

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNK3 inhibitor-7 is a potent, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 53, 973, 1039 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-7 shows significant neuroprotective effects. JNK3 inhibitor-7 has the potential for the research of Alzheimer’s disease (AD)[1].

IC50 & Target[1]

JNK3

53 nM (IC50)

JNK2

973 nM (IC50)

JNK1

1039 nM (IC50)

体外研究
(In Vitro)

JNK3 inhibitor-7 (compound 2h; 20 µM; 24, 48 h) 增加用 10 μM amyloid-β1-42处理的原代大鼠皮层神经元细胞活力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNK3 inhibitor-7 相关抗体:

Cell Viability Assay[1]

Cell Line: primary rat cortex neuron cells
Concentration: 20 µM
Incubation Time: 24, 48 h
Result: Increased cell viability when treatment with 10 μM amyloid-β1-42.
体内研究
(In Vivo)

JNK3 inhibitor-7 (30、60 mg/kg；口服；每日一次，持续 4 周) 对小鼠显示出显着的神经保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7 month-old APP/PS1 AD mice[1]
Dosage: 30, 60 mg/kg
Administration: P.o.; daily for 4 weeks
Result: Decreased the escape time and distance traveled, a dose-dependent increased in the quadrant where the escape zone was located and the time spent.
分子量

561.63

Formula

C32H31N7O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNK3 inhibitor-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK3 inhibitor-7JNKc-Jun N-terminal kinaseorally activecross the blood-brain barrierAlzheimer’s diseaseneuroprotectiveInhibitorinhibitorinhibit

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