2. Membrane Transporter/Ion Channel
  3. CFTR
  4. K41498 TFA

K41498 TFA 是一种强选择性的 CRF2 receptor 拮抗剂，其对人 CRF2α、CRF2β 和 CRF1 受体的 Ki 值分别为 0.66 nM、0.62 nM和425 nM。K41498 TFA 是 antisauvagine-30 (aSvg-30) 的类似物，可抑制 sauvagine 刺激的 cAMP 在 hCRF2α/hCRF2β 表达细胞中的积累。K41498 可用于低血压研究。

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Custom Peptide Synthesis

K41498 TFA Chemical Structure

K41498 TFA Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥4100
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Other Forms of K41498 TFA:

K41498 TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

K41498 TFA is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively. K41498 TFA is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. K41498 TFA can be used for hypotension study[1].

分子量

3632.20 (free base)

Formula

C162H276N48O46.xC2HF3O2
性状

固体

颜色

White to off-white

Sequence

{D-Phe}-His-Leu-Leu-Arg-Lys-{Nle}-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2
Sequence Shortening

{D-Phe}-HLLRK-{Nle}-IEIEKQEKEKQQAANNRLLLDTI-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

K41498 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K41498K 41498K-41498CFTRCystic fibrosis transmembrane conductance regulatorCRF2 receptorhypotensionInhibitorinhibitorinhibit

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产品名称：
K41498 TFA
目录号：
HY-P1106A
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