Kaliotoxin 

Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability^[1][2].

Kd: 20 nM (KCa channel)^[1]

Kaliotoxin (KTX) (250 nM) specifically suppressed the whole cell Ca2⁺-activated K⁺ current^[1].
Kaliotoxin interacts in a one-to-one way with KCa channels with a K_d of 20 nM^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kaliotoxin facilitates cognitive processes by the blockage of Kv1.1 or Kv1.3 channels^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4149.94

C₁₇₁H₂₈₃N₅₅O₄₉S₈

145199-73-1

Gly-Val-Glu-Ile-Asn-Val-Lys-Cys-Ser-Gly-Ser-Pro-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-His-Cys-Thr-Pro-Lys (Disulfide bridge: Cys8-Cys28;Cys14-Cys33;Cys18-Cys35)

GVEINVKCSGSPQCLKPCKDAGMRFGKCMNRKCHCTPK (Disulfide bridge: Cys8-Cys28;Cys14-Cys33;Cys18-Cys35)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. M Crest, et al. Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom. J Biol Chem. 1992 Jan 25;267(3):1640-7.  [Content Brief]

  [2]. S Kourrich, et al. Kaliotoxin, a Kv1.1 and Kv1.3 channel blocker, improves associative learning in rats. Behav Brain Res. 2001 Apr 8;120(1):35-46.  [Content Brief]