2. Cell Cycle/DNA Damage
  3. IRE1
  4. Kira8 Hydrochloride

Kira8 Hydrochloride  (Synonyms: AMG-18 Hydrochloride)

目录号: HY-114368A
产品使用指南

摩尔计算器

Kira8 Hydrochloride (AMG-18 Hydrochloride) 是一种单选择性 IRE1α 抑制剂，可以变构减弱 IRE1α RNase 活性，IC50 为 5.9 nM。

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Kira8 Hydrochloride Chemical Structure

Kira8 Hydrochloride Chemical Structure

CAS No. : 2250019-92-0

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Kira8 Hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Kira8 Hydrochloride:

Kira8 Hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM[1].

IC50 & Target

IRE1α[1]
IC50: 5.9 nM (IRE1α RNase)[1]
体外研究
(In Vitro)

Kira8 blocks IRE1α oligomerization, and potently inhibits IRE1α RNase activity against XBP1 and Ins2 RNAs. Kira8 more potently reduces IRE1α-driven apoptosis in INS-1 cells than KIRA6 and also reverses XBP1 splicing promoted by GNF-2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kira8 Hydrochloride 相关抗体:
体内研究
(In Vivo)

Male Ins2+/Akita mice are injected i.p. with KIRA8 (50 mg/kg; daily; for 35 days), significant reduction of hyperglycemia become apparent over several weeks[1].
One week treatment of pre-diabetic NODs mice with Kira8 (50 mg/kg; i.p.; once a day) leads to significant reductions in islet XBP1 splicing and TXNIP mRNAs, and preserves Ins1/Ins2, BiP and MANF mRNAs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Ins2+/Akita mice[1]
Dosage: 50 mg/kg
Administration: Injected i.p.; daily; for 35 days
Result: Significant reduction of hyperglycemia became apparent over several weeks.
分子量

637.58

Formula

C31H30Cl2N6O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Kira8 Hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kira82250019-92-0AMG-18Kira 8Kira-8AMG18AMG 18IRE1Inositol requiring enzyme 1Inhibitorinhibitorinhibit

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目录号：
HY-114368A
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