2. Stem Cell/Wnt Apoptosis
  3. YAP Apoptosis
  4. Lappaol F

Lappaol F，一种木质素，是一种抗癌剂。Lappaol F 抑制 YAP<、b> mRNA 和蛋白质水平。Lappaol F 通过诱导细胞周期停滞来抑制肿瘤细胞生长。Lappaol F 诱导癌细胞 (apoptosis)，并抑制肿瘤生长。Lappaol F 可以从牛蒡子 (Asteraceae) 中分离出来。

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Lappaol F Chemical Structure

Lappaol F Chemical Structure

CAS No. : 69394-17-8

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1 mg ￥6600
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Lappaol F 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lappaol F, a lignin, is an anticancer agent. Lappaol F inhibits YAP<、b> mRNA and protein level. Lappaol F inhibits tumor cell growth by inducing cell cycle arrest. Lappaol F induces cancer cell apoptosis, and inhibits tumor growth. Lappaol F can be isolated from Arctium lappa Linne (Asteraceae)[1].

体外研究
(In Vitro)

Lappaol F (72 h) 抑制 HeLa、MDA-MB-231、SW480 和 PC3 细胞的增殖，IC50 值分别为 41.5、26.0、45.3 和 42.9 μM，并诱导细胞凋亡[1]。
Lappaol F (50 μM，12/24/36 h) 降低 HeLa、MDA-MB-231、SW480 和 PC3 细胞中 YAP 及其靶基因 (例如 BIRC5、GLI2、c-Myc、Bcl-2、Axin2 和 AREG) 的转录水平[1]。
Lappaol F (0-50 μM，24-72 小时) 可降低 HeLa 细胞中的 YAP 蛋白水平、核定位和转录活性[1]。
Lappaol F (50 μM，24-72 小时) 可诱导 HeLa、MDA-MB-231、MCF-7 细胞出现 G1 和 G2 细胞周期停滞[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lappaol F 相关抗体:

Immunofluorescence[1]

Cell Line: HeLa cells
Concentration: 50 μM
Incubation Time: 48 h
Result: Decreased the nuclear accumulation of YAP.

Western Blot Analysis[2]

Cell Line: HeLa、MDA-MB-231、MCF-7 cells
Concentration: 50 μM
Incubation Time: 24, 48, 72 h
Result: Increased level of p21 and p27, and reduced level of CDK2, cyclin B1, and CDK1.

RT-PCR[1]

Cell Line: HeLa, MDA-MB-231, SW480 and PC3 cells
Concentration: 50 μM
Incubation Time: 12/24/36 h
Result: Lowered transcriptional levels of YAP and its target genes (such as BIRC5, GLI2, c-Myc, Bcl-2, Axin2 and AREG).
Upregulated 14-3-3σ mRNA level.
体内研究
(In Vivo)

Lappaol F (10 和 20 mg/kg/d，静脉注射，15 天) 抑制裸鼠体内人结肠癌 (SW480) 异种移植物的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human colon cancer (SW480) xenografts in nude mice[1]
Dosage: 10 and 20 mg/kg/d
Administration: i.v., 15 days
Result: Inhibited tumor size by 48% (10 mg/kg/d) and 55% (20 mg/kg/d) without affecting the body weight.
Induced apoptosis in tumor tissues.
Up-regulated the levels of 14-3-3σin tumor tissues and down-regulated the levels of YAP.
分子量

714.75

Formula

C40H42O12
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Lappaol F 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lappaol F69394-17-8YAPApoptosisYes-associated proteinanticancerligninHeLaMDA-MB-231SW480PC3colon cancerInhibitorinhibitorinhibit

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