2. Apoptosis
  3. TNF Receptor
  4. Letolizumab

Letolizumab  (Synonyms: BMS-986004)

目录号: HY-P99701 纯度: 95.00%
COA

摩尔计算器

Letolizumab (BMS-986004) 是一种靶向 CD40L 的单克隆抗体，其产生是为了表达缺乏效应器功能的突变 IgG1，包括 Fc 结合和补体固定。Letolizumab 降低了排斥反应、血栓栓塞，延长了存活时间。

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Letolizumab Chemical Structure

Letolizumab Chemical Structure

CAS No. : 1450981-87-9

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5 mg ￥6800
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Customer Review

Letolizumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Letolizumab (BMS-986004) is a monoclonal antibody targeting CD40L, which is produced to express mutant IgG1 lacking effector function, including Fc binding and complement fixation. Letolizumab reduces rejection, thromboembolism and prolongs the survival time[1][2][3].

IC50 & Target[1]

CD40L

 

体内研究
(In Vivo)

Letolizumab 抑制 CD40L 三聚体和 CHO-CD40L 在人类 B 细胞 (IC50 值分别为 3.6 nM 和 1.3 nM) 或非人类灵长类 B 细胞 (IC50 值分别为 3.8 nM 和 7.3 nM) 中的活力[2]。
Letolizumab (2、10 和 20 mg/kg；静脉注射；一周一次持续 10 周) 延长了肾移植后的恒河猴的存活时间[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rhesus macaques after renal transplantation[2].
Dosage: 2, 10 and 20 mg/kg.
Administration: Intravenous injection; once a week for 10 weeks.
Result: Increased the survival time.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Letolizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Letolizumab1450981-87-9BMS-986004BMS986004BMS 986004TNF ReceptorTumor Necrosis Factor ReceptorTNFRCD40LCHO-CD40L Rhesus macaquesInhibitorinhibitorinhibit

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