2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. CDK E1/E2/E3 Enzyme
  4. LO-3-63

LO-3-63 是一种 Ribociclib (HY-15777) 类似物，带有截短的富马酰胺基团，属于具有 PROTAC 特性的 CDK4/6 降解剂。LO-3-63 通过 CUL4DCAF16 依赖性途径降解细胞中的 CDK4/6。

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LO-3-63

LO-3-63 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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LO-3-63 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LO-3-63, a Ribociclib (HY-15777) analog bearing a truncated fumaramide handle, is a PROTAC-like CDK4/6 degrader. LO-3-63 induces CUL4DCAF16-dependent degradation of CDK4/6 in cells[1].

体外研究
(In Vitro)

LO-3-63 (1-10 μM, 12-24 h) 在 HEK293T 细胞中通过蛋白酶体介导 CDK4/6 的降解，这一效应在 DCAF16 敲除细胞中可被抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LO-3-63 相关抗体:

Western Blot Analysis[1]

Cell Line: HEK293T cells (WT, DCAF16 KO)
Concentration: 1, 5, 10 μM
Incubation Time: 12, 24 h
Result: Degraded CDK4/6 in HEK293T cells (WT), an effect that can be attenuated in DCAF16 KO cells.
分子量

643.14

Formula

C32H35ClN10O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LO-3-63 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LO-3-63CDKE1/E2/E3 EnzymeCyclin dependent kinaseE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseDCAF16HEK293T cellsCDK4/6Inhibitorinhibitorinhibit

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产品名称：
LO-3-63
目录号：
HY-175187
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