1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK14 Isoform

CDK14

CDK14, also named PFTAIREI, is a CDC2-associated serine/threonine protein kinase and can act as an essential regulator of CCNs and cell cycle development. Interestingly, CDK14 can regulate cell cycle progression and cell proliferation by interacting with CCNY that is the regulatory submit of CDK14 and promotes Wnt signaling by mediating cell cycle-dependent low-density-lipoprotein receptor-related protein 6 (LRP6) phosphorylation which is a key regulatory nexus in Wnt/β-catenin pathway.

CDK14 相关产品 (3):

目录号 产品名 作用方式 纯度
  • HY-127104
    FMF-04-159-2 Inhibitor 98.92%
    FMF-04-159-2 是一种有效的共价 CDK14 抑制剂。FMF-04-159-2 抑制 CDK14CDK2,在 NanoBRET 试验中 IC50 分别为 39.6 nM 和 256 nM。
  • HY-X0150
    JSH-150 Inhibitor 98.36%
    JSH-150 是一种高效的选择性 CDK9 抑制剂, IC50 为 1 nM。
  • HY-160213
    JA397 Inhibitor
    JA397 是一种有效的选择性的 TAIRE 家族抑制剂,其细胞活性范围为 IC50 21 nM至 307 nM。