2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. LP 12 hydrochloride

LP 12 hydrochloride (compound 21) 是一种有效的选择性 5-HT7 受体激动剂，Ki 为 0.13 nM。LP 12 hydrochloride 对 5-HT7 的选择性优于 D2、5-HT1A 和 5-HT2A 受体 (Ki 值分别为 224 nM、60.9 nM 和 >1000 nM)。

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LP 12 hydrochloride Chemical Structure

LP 12 hydrochloride Chemical Structure

CAS No. : 1185136-22-4

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LP 12 hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of LP 12 hydrochloride:

LP 12 hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LP 12 hydrochloride (compound 21) is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively)[1][2].

IC50 & Target[1]

5-HT7 Receptor

0.13 nM (IC50)

5-HT1A Receptor

60.9 nM (IC50)

5-HT2A Receptor

1464 nM (IC50)

体外研究
(In Vitro)

LP 12 hydrochloride (0.13 nM; spermatozoa) increases the percentage of hyperactivated spermatozoa. LP 12 hydrochloride do not affect straight-line velocity (VSL), curvilinear velocity (VCL), average-path velocity (VAP), linearity (LIN), straightness (STR), wobbler coefficient (WOB), amplitude of lateral head displacement (ALH), and beat-cross frequency (BCF)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LP 12 hydrochloride 相关抗体:
分子量

518.13

Formula

C32H40ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LP 12 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LP 121185136-22-4LP12LP-125-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorpronociceptive effectshyperactivated spermatozoastraight-line velocitycurvilinear velocityInhibitorinhibitorinhibit

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产品名称：
LP 12 hydrochloride
目录号：
HY-103105
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