2. Apoptosis
  3. Survivin Apoptosis
  4. LQZ-7F

LQZ-7F 是一种生存素二聚化 (survivin dimerization) 抑制剂，可在前列腺癌细胞中诱导自发细胞凋亡 (apoptosis) 并与多西紫杉醇协同作用。LQZ-7F 剂量依赖性地抑制 PC-3 和 C4-2 细胞的存活，IC50 分别为 2.99 和 2.47 µM。

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LQZ-7F Chemical Structure

LQZ-7F Chemical Structure

CAS No. : 354543-09-2

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1 mg ￥1600
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5 mg ￥4800
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LQZ-7F 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LQZ-7F, a survivin dimerization inhibitor, induces spontaneous apoptosis and synergizes with Docetaxel in prostate cancer cells. LQZ-7F dose-dependently inhibits survival of both PC-3 and C4-2 cells with IC50s of 2.99 and 2.47 µM, respectively[1].

体外研究
(In Vitro)

LQZ-7F could be hudrolyzed under acidic conditions[1].
LQZ-7F (2.5 μM, 72 hours) displays cytotoxicity towards human cancer cells (PC-3, C4-2) with the IC50s of 2.99 μM and 2.74 μM, respectively[1].
LQZ-7F effectively inhibits survival of all cancer cell lines with IC50 values ranging between 0.4 and 4.4 mM[2].
LQZ-7F (2 μM, 24 hours) disrupts microtubule structure and cause mitotic arrest in P3 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LQZ-7F 相关抗体:

Apoptosis Analysis[1]

Cell Line: PC3, HL-60 cells
Concentration: 0, 5, 10 μM
Incubation Time:
Result: Caused 54% to 69% apoptosis for PC3 and 66% to 98% apoptosis for HL-60 cells.

Cell Cytotoxicity Assay[1]

Cell Line: PC-3, DU145
Concentration: 10, 20 μM
Incubation Time: 72 hours
Result: Showed that the IC50 in human PC3 and DU145 cells was approximately 25 μM.
体内研究
(In Vivo)

LQZ-7F (i.p. injection; 25 mg/kg once every 3 days; 24 days) inhibits growth of xenograft tumor and may be due to its induction of surviving degradation in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4- to 6-week-old male NSG (NOD/SCID/IL-2Rg null) mice[2].
Dosage: 25 mg/kg
Administration: 24 days
Result: Inhibited growth of xenograft tumors by inhibiting surviving.
分子量

349.26

Formula

C14H7N9O3
CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 5 mg/mL (14.32 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8632 mL 14.3160 mL 28.6320 mL
5 mM 0.5726 mL 2.8632 mL 5.7264 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

LQZ-7F 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8632 mL 14.3160 mL 28.6320 mL 71.5799 mL
5 mM 0.5726 mL 2.8632 mL 5.7264 mL 14.3160 mL
10 mM 0.2863 mL 1.4316 mL 2.8632 mL 7.1580 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LQZ-7F354543-09-2SurvivinApoptosissurvivin dimerizationapoptosisDocetaxelprostate cancer cellsPC-3 and C4-2Inhibitorinhibitorinhibit

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