2. Protein Tyrosine Kinase/RTK Apoptosis
  3. SHP2 Apoptosis
  4. LXQ-217

LXQ-217 是一种口服活性 SHP2 抑制剂，其 IC50 值为 2.01 μM。LXQ-217 在诱导细胞凋亡 (apoptosis)，在体内外抑制细胞生长。

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LXQ-217 Chemical Structure

LXQ-217 Chemical Structure

CAS No. : 2524718-79-2

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LXQ-217 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LXQ-217 is an oral active SHP2 inhibitor with the IC50 of 2.01 μM. LXQ-217 induces apoptosis and inhibits cell growth in vivo and in vitro[1].

体外研究
(In Vitro)

LXQ-217 (72 h) 对 A549、HCT116、HepG2 和 MDA-MB-231 细胞有抑制作用，IC50 值分别为 2.06、3.88、4.53 和 5.13 μM[1]。
LXQ-217 (2.5, 5, 10 μM, 7 days) 可以降低 A549 细胞的克隆数量和形成率[1]。
LXQ-217 (1.25, 2.5 μM, 24 h) 抑制 A549 细胞的迁移[1]。
LXQ-217(2.5、5、10 μM, 3 h) 增加 A549 细胞中切割-parp (C-parp)、切割-caspase9 (C-cas9) 和切割-caspase3 (C-cas3) 的蛋白水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LXQ-217 相关抗体:

Cell Migration Assay [1]

Cell Line: A549 cells
Concentration: 1.25 and2.5 μM
Incubation Time: 72 h
Result: Inhibited the migration of A549 cells.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 2.5, 5 and 10 μM
Incubation Time: 3 h
Result: Increased the levels cleaved-parp (C-parp), cleaved-caspase9 (C-cas9) and cleaved-caspase3 (C-cas3) in A549 cells.
体内研究
(In Vivo)

LXQ-217 (50, 100mg/kg; Oral administration for 14 days) 可抑制 BALB/c 裸鼠构建的 A549 细胞异种移植模型的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A549 cell xenograft model constructed based on BALB/c-nude mice[1]
Dosage: 50 or 100mg/kg
Administration: Oral administration for 14 days
Result: Lowered tumor weight and volume of mice.
分子量

576.23

Formula

C24H20Br2N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LXQ-217 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LXQ-2172524718-79-2LXQ217LXQ 217SHP2ApoptosisSrc homology phosphatase 2PTPN11Lung CancerA549HCT116HepG2MDA-MB-231Inhibitorinhibitorinhibit

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产品名称：
LXQ-217
目录号：
HY-161360
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