1. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
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  3. Malvidin-3-galactoside chloride

Malvidin-3-galactoside chloride  (Synonyms: 氯化锦葵色素-3-O-半乳糖苷)

目录号: HY-N6623
产品使用指南

Malvidin-3-galactoside chloride 是一种花青素单体,可诱导肝细胞癌 (HCC) 细胞周期停滞和凋亡。Malvidin-3-galactoside chloride 抑制 ROS 的产生和积累。Malvidin-3-galactoside chloride 具有抗肿瘤功能。

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Malvidin-3-galactoside chloride Chemical Structure

Malvidin-3-galactoside chloride Chemical Structure

CAS No. : 30113-37-2

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  • 生物活性

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生物活性

Malvidin-3-galactoside chloride, an anthocyanin monomer, induces hepatocellular carcinoma (HCC) cells cycle arrest and apoptosis. Malvidin-3-galactoside chloride inhibits the production and accumulation of ROS. Malvidin-3-galactoside chloride has anti-tumor function[1].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Malvidin-3-galactoside chloride (50, 100, 200 μg/mL; for 24, 48, 72 h) displays obvious cytotoxicity on Huh-7 cells and has no significant effect with 50 and 100 μg/mL for 48 h. Malvidin-3-galactoside chloride has a notable cytotoxic effect against Huh-7 cells at 72 h[1].
Malvidin-3-galactoside chloride (50-200 μg/mL) arrests the cells in the S phase, accompanied by the cells in the G1 phase decreased, and the cells in the S phase increased[1].
Malvidin-3-galactoside chloride (50-200 μg/mL; for 72 h) induces cell apoptosis in Huh-7 cells[1].
Malvidin-3-galactoside chloride (50-200 μg/mL; for 72 h) markedly increased the levels of caspase-3, cleaved-caspase-3 and cleaved-PARP in a dose-dependent manner[1].
Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) inhibits the production and accumulation of ROS[1].
Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) dramatically reduces the level of phosphorylation ERK (p-ERK) in a dose-dependent manner. Malvidin-3-galactoside chloride with 200 μg/mL markedly increases the phosphorylation level of p38 and JNK (p-p38 and p-JNK)[1].
Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) inhibits the migration and invasion in Huh-7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

528.89

Formula

C23H25ClO12

CAS 号
中文名称

氯化锦葵色素-3-O-半乳糖苷

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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