2. Anti-infection Neuronal Signaling
  3. Bacterial Monoamine Oxidase
  4. MAO-A/B-IN-4

MAO-A/B-IN-4 是一种口服活性的 MAO-A/B 抑制剂，IC50 值分别为 51.3 μM 和 47.0 μM。MAO-A/B-IN-4 对 S. aureus、MSSA、MRSA、LRSA 和 LREFa 显示出强效活性。MAO-A/B-IN-4 在小鼠 LRSA 腹膜炎感染模型中表现出显著的抗菌功效。MAO-A/B-IN-4 可用于细菌感染的研究。

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MAO-A/B-IN-4

MAO-A/B-IN-4 Chemical Structure

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MAO-A/B-IN-4 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-A/B-IN-4 is an orally active MAO-A/B inhibitor, with IC50 values of 51.3 μM and 47.0 μM, respectively. MAO-A/B-IN-4 exhibits potent activity against S. aureus, MSSA, MRSA, LRSA, and LREFa. MAO-A/B-IN-4 demonstrates potent antibacterial efficacy in a mouse model of LRSA peritonitis infection. MAO-A/B-IN-4 can be used for the study of bacterial infections[1].

体外研究
(In Vitro)

MAO-A/B-IN-4 (Compound D13) 对 S. aureus、MSSA、MRSA、LRSA 和 LREFa 表现出强效的抗菌活性，其 MIC 值均小于 1 μg/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-A/B-IN-4 相关抗体:
体内研究
(In Vivo)

MAO-A/B-IN-4 (Compound D13) (2.5-40 mg/kg，灌胃，在感染后 5 分钟和 6 小时给药) 在 ICR 小鼠 LRSA 腹膜炎感染模型中表现出剂量依赖的体内抗菌效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LRSA20-2 bacterial suspension (0.5 mL, 3.5×107 CFU/mL) was intraperitoneally injected into ICR mice to construct the LRSA peritonitis infection model[1]
Dosage: 2.5, 10, 40 mg/kg
Administration: i.g., administration time: 5 min and 6 h post-infection
Result: Achieved survival rates of 0%, 12.5%, and 100% at doses of 2.5, 10, and 40 mg/kg, respectively.
Showed no significant acute toxicity.
分子量

469.44

Formula

C22H21F2N7O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-A/B-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-A/B-IN-4BacterialMonoamine OxidaseMAOS. aureusLRSAMAO-A/Bbacterial infectionMSSALREFaInhibitorinhibitorinhibit

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