2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-21

MAO-B-IN-21 是一种有效的 MAO-B 抑制剂，具有抗氧化活性和抗 Aβ 聚集活性。MAO-B-IN-21 还具有金属离子螯合能力、抗神经炎症（NO、TNF-α）、神经保护活性和 BBB 通透性。MAO-B-IN-21 显着改善 Aβ1-42 诱导的阿尔茨海默病小鼠模型的记忆和认知障碍。

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MAO-B-IN-21 Chemical Structure

MAO-B-IN-21 Chemical Structure

CAS No. : 2956426-18-7

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MAO-B-IN-21 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-21 is an excellent MAO-B inhibitor with antioxidant activity and anti-Aβ aggregation activity. MAO-B-IN-21 also exhibits metal-ion chelating ability, anti-neuroinflammation (NO, TNF-α), neuroprotective activity and BBB permeability. MAO-B-IN-21 significantly improves the memory and cognitive impairment in Aβ1-42 induced Alzheimer's disease mice model[1].

IC50 & Target[1]

MAO-B

 

体外研究
(In Vitro)

MAO-B-IN-21 (37.5 μM 甲醇溶液) 阻断 Cu2+ 诱导的 ROS 产生，这是由于它的金属螯合特性和/或其抗氧化能力，而能够从 Cu2+-抗坏血酸氧化还原系统捕获自由基[1]。
MAO-B-IN-21 (25 μM; 24 h; 37 ℃) 抑制自诱导的 Aβ1-42 聚集并分解自诱导的 Aβ1-42 原纤维[1]。
MAO-B-IN-21 (2.5-25 μM；24 小时) 抑制 LPS 刺激的 BV-2 小胶质细胞中 ROS 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-21 相关抗体:
体内研究
(In Vivo)

MAO-B-IN-21 (30 mg/kg；ig；单次剂量) 可以在 Balb/C 小鼠中轻松透过血脑屏障[1]。
MAO-B-IN-21 (8 mg/kg 和 32 mg/kg；ig；单剂量) 缩短逃逸潜伏期 (ELT)，降低 Aβ1-42 水平，表明 Aβ 诱导的 AD 小鼠模型的学习和记忆能力得到改善 [1]。

在 Balb/C 小鼠中的药代动力学分析[1]

Tissue T1/2 Tmax Cmax AUC0-t AUCbrain/plasma
Plasma 1.15 h 0.5 h 1539 ng/mL 2941 ng·h/mL 0.69
Brain 2.07 h 1.0 h 922.7 ng/g 2032.5 ng·h/g

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

440.92

Formula

C24H25ClN2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-21 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-212956426-18-7Monoamine OxidaseMAOInhibitorinhibitorinhibit

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