2. Neuronal Signaling Metabolic Enzyme/Protease
  3. Monoamine Oxidase Amylases
  4. MAO-B-IN-46

MAO-B-IN-46  (Synonyms: (4-氯苯甲酰)苯并呋喃)

目录号: HY-W207699
产品使用指南 技术支持

MAO-B-IN-46 (Compound 16) 是一种选择性 hMAO-B 抑制剂 (IC50: 26.8 nM)，对 hMAO-A 活性较弱 (IC50: 7.2054 μM) 。MAO-B-IN-46 (Compound 8) 也是一种 α-淀粉酶抑制剂 (IC50: 19.46 μM)。MAO-B-IN-46 有一定的神经保护作用，对人牙龈成纤维细胞和 SH-SY5Y 细胞无显著毒性。MAO-B-IN-46 也可清除 DPPH、ABTS 自由基，IC50 分别为 17.86 和 17.71 μM。MAO-B-IN-46 可用于帕金森等神经退行性疾病、糖尿病及抗氧化应激疾病的研究。

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MAO-B-IN-46

MAO-B-IN-46 Chemical Structure

CAS No. : 27052-20-6

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MAO-B-IN-46 相关抗体

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查看 Monoamine Oxidase 亚型特异性产品:

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MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC50: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance[1][2].

IC50 & Target[1]

hMAO-A

7.2054 μM (IC50)

hMAO-B

26.8 nM (IC50)

分子量

256.68

Formula

C15H9ClO2
CAS 号
中文名称

(4-氯苯甲酰)苯并呋喃
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-46 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-4627052-20-6(4-氯苯甲酰)苯并呋喃Monoamine OxidaseAmylasesMAOhuman gingival fibroblastsSH-SY5Y cellsPDdiabetesoxidative stressInhibitorinhibitorinhibit

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