2. Academic Validation
  3. Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity

Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity

  • Bioorg Med Chem Lett. 2001 May 7;11(9):1173-6. doi: 10.1016/s0960-894x(01)00165-2.
N H Nam 1,  Y J You,  Y Kim,  D H Hong,  H M Kim,  B Z Ahn
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungnam National University, Taejon, South Korea.
PMID: 11354370 DOI: 10.1016/s0960-894x(01)00165-2
Abstract

A series of 3-aryl-2-propenoates including cinnamates, (E)-methyl/ethyl 3-[2-(1,4-dimethoxy-5,8-dione)naphthalenyl]-2-propenoates (8ba, 8bb) and (E)-methyl/ethyl 3-[2-(1,4-dihydroxy-9,10-dione)anthracenyl]-2-propenoates (9aa,9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the ortho- or para-dihydroxy funtionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab showed potent cytotoxicity against various tumor cell lines.

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