2. Academic Validation
  3. Synthesis and cytotoxicity of 2alpha-amido docetaxel analogues

Synthesis and cytotoxicity of 2alpha-amido docetaxel analogues

  • Bioorg Med Chem Lett. 2002 Jun 3;12(11):1543-6. doi: 10.1016/s0960-894x(02)00118-x.
Wei-Shuo Fang 1,  Ying Liu,  Hong-Yan Liu,  Shao-Feng Xu,  Liang Wang,  Qi-Cheng Fang
Affiliations

Affiliation

  • 1 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, PR China. wfang@imm.ac.cn
PMID: 12031338 DOI: 10.1016/s0960-894x(02)00118-x
Abstract

Various 2-amido docetaxel analogues were prepared and evaluated for their cytotoxicities. Among them, m-methoxy and m-chlorobenzoylamido analogues were most active but not superior to docetaxel and paclitaxel, and D-seco analogues inactive. Change of 2-benzoate to 2-benzamide may not improve their activities to drug-resistant cell lines.

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