2. Academic Validation
  3. New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles

New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles

  • Bioorg Med Chem Lett. 2002 Dec 2;12(23):3487-90. doi: 10.1016/s0960-894x(02)00746-1.
Andrew Fensome 1,  Reinhold Bender,  Jeffrey Cohen,  Mark A Collins,  Valerie A Mackner,  Lori L Miller,  John W Ullrich,  Richard Winneker,  Jay Wrobel,  Puwen Zhang,  Zhiming Zhang,  Yuan Zhu
Affiliations

Affiliation

  • 1 Chemical Sciences, Wyeth Research, Collegeville, PA 19426, USA. fensoma@wyeth.com
PMID: 12419390 DOI: 10.1016/s0960-894x(02)00746-1
Abstract

A new series of 3,3-disubstituted-5-aryloxindoles has been synthesized and evaluated for Progesterone Receptor antagonist (PR) activity in a T47D cell Alkaline Phosphatase assay and for their ability to bind PR in competition binding studies. In this communication, the synthesis and structure-activity relationships (SARs) of various 3,3-substituents are discussed where it is clear that small alkyl and spiroalkyl groups are required to achieve better PR antagonist activity.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z