2. Academic Validation
  3. De novo synthesis of two new cytotoxic tiazofurin analogues with modified sugar moieties

De novo synthesis of two new cytotoxic tiazofurin analogues with modified sugar moieties

  • Bioorg Med Chem Lett. 2003 Oct 6;13(19):3167-70. doi: 10.1016/s0960-894x(03)00712-1.
Mirjana Popsavin 1,  Ljilja Torović,  Vesna Kojić,  Gordana Bogdanović,  Sasa Spaić,  Velimir Popsavin
Affiliations

Affiliation

  • 1 Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia and Montenegro, Yugoslavia. popsavin@ih.ns.ac.yu
PMID: 12951086 DOI: 10.1016/s0960-894x(03)00712-1
Abstract

A divergent synthesis of two novel tiazofurin analogues, 2-(3-deoxy-3-fluoro-beta-D-xylofuranosyl)thiazole-4-carboxamide (2) and 2-(3-acetamido-3-deoxy-beta-D-xylofuranosyl)thiazole-4-carboxamide (3), has been achieved starting from D-glucose. Both nucleoside analogues were evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.

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