2. Academic Validation
  3. Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes

Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes

  • Bioorg Med Chem Lett. 2006 Oct 15;16(20):5457-61. doi: 10.1016/j.bmcl.2006.07.057.
Heinrich Berger 1,  Werner Seebacher,  Robert Saf,  Marcel Kaiser,  Reto Brun,  Robert Weis
Affiliations

Affiliation

  • 1 Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University, Universitätsplatz 1, A-8010 Graz, Austria.
PMID: 16889962 DOI: 10.1016/j.bmcl.2006.07.057
Abstract

The in vitro activity of newly synthesized bis-(chlorophenyl)-azabicyclo[3.2.2]nonanes and bis-(chlorophenyl)-bicyclo[2.2.2]octanes against Plasmodium falciparum K(1) (resistant to chloroquine and pyrimethamine) and Trypanosoma brucei rhodesiense was investigated. Especially the bis-(chlorophenyl)-azabicyclo[3.2.2]nonanes exhibit promising antitrypanosomal activity and were tested in vivo against Trypanosoma brucei brucei featuring moderate activities.

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