2. Academic Validation
  3. Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity

Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity

  • Bioorg Med Chem Lett. 2008 Mar 1;18(5):1725-9. doi: 10.1016/j.bmcl.2008.01.042.
Monika Ermann 1,  Doris Riether,  Edward R Walker,  Innocent F Mushi,  James E Jenkins,  Beatriz Noya-Marino,  Mark L Brewer,  Malcolm G Taylor,  Patricia Amouzegh,  Stephen P East,  Brian W Dymock,  Mark J Gemkow,  Andreas F Kahrs,  Andreas Ebneth,  Sabine Löbbe,  Kathy O'Shea,  Daw-Tsun Shih,  David Thomson
Affiliations

Affiliation

  • 1 Evotec (UK) Ltd., 114 Milton Park, Abingdon, Oxfordshire OX14 4SA, United Kingdom. monika.ermann@evotec.com
PMID: 18255291 DOI: 10.1016/j.bmcl.2008.01.042
Abstract

A high-throughput screening campaign resulted in the discovery of a highly potent dual Cannabinoid Receptor 1 (CB1) and 2 (CB2) agonist. Following a thorough SAR exploration, a series of selective CB2 full agonists were identified.

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