2. Academic Validation
  3. Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors

Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors

  • Bioorg Med Chem Lett. 2008 Sep 15;18(18):4929-31. doi: 10.1016/j.bmcl.2008.08.060.
Casey C McComas 1,  An T Vu,  Paige E Mahaney,  Stephen T Cohn,  Andrew Fensome,  Michael A Marella,  Lisa Nogle,  Eugene J Trybulski,  Fei Ye,  Puwen Zhang,  Peter Alfinito,  Jenifer Bray,  Grace Johnston,  Elizabeth Koury,  Darlene C Deecher
Affiliations

Affiliation

  • 1 Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, S2227A, Collegeville, PA 19426, USA. mccomac@wyeth.com
PMID: 18771916 DOI: 10.1016/j.bmcl.2008.08.060
Abstract

Norepinephrine and serotonin play an important role in a wide variety of biological processes and are implicated in a number of neurological disorders. A novel class of 1-(3-amino-1-phenylpropyl)indolin-2-ones was designed and synthesized that displays potent norepinephrine reuptake inhibition while maintaining high selectivity (>100-fold) against the human serotonin and dopamine transporters.

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