2. Academic Validation
  3. 3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors

3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors

  • Bioorg Med Chem Lett. 2009 May 1;19(9):2464-7. doi: 10.1016/j.bmcl.2009.03.054.
An T Vu 1,  Stephen T Cohn,  Eugene A Terefenko,  William J Moore,  Puwen Zhang,  Paige E Mahaney,  Eugene J Trybulski,  Igor Goljer,  Rebecca Dooley,  Jenifer A Bray,  Grace H Johnston,  Jennifer Leiter,  Darlene C Deecher
Affiliations

Affiliation

  • 1 Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA.
PMID: 19329313 DOI: 10.1016/j.bmcl.2009.03.054
Abstract

A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the Dopamine Transporter.

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