2. Academic Validation
  3. A need for speed: genetic encoding of rapid cycloaddition chemistries for protein labelling in living cells

A need for speed: genetic encoding of rapid cycloaddition chemistries for protein labelling in living cells

  • Chembiochem. 2012 Jul 23;13(11):1553-7. doi: 10.1002/cbic.201200321.
Moritz J Schmidt 1,  Daniel Summerer
Affiliations

Affiliation

  • 1 Fachbereich Chemie, Universität Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.
PMID: 22753121 DOI: 10.1002/cbic.201200321
Abstract

Rapid reactions: Several reactants for strain-promoted cycloaddition reactions have been genetically encoded as the side chains of noncanonical Amino acids. This results in decisive improvements for the fluorescent labelling of intracellular proteins such as quantitative turnover, completion of labelling reactions within minutes, fluorogenic effects and even partial orthogonality for multicolour labelling.

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